UNCOUPLING OF OXIDATIVE PHOSPHORYLATION BY CADMIUM ION
نویسندگان
چکیده
منابع مشابه
Uncoupling of oxidative phosphorylation by cadmium ion.
Mitochondria from rat liver were isolated in 0.25 M sucrose according to Schneider (5) and suspended in 1 ml. of 0.25 M sucrose per gm. of fresh liver. Rabbit liver mitochondria, used only for the experiments in Table I, were prepared by grinding the tissue in 0.25 M sucrose in a Waring blendor at reduced speed (6) and were suspended in 1 ml. of sucrose solution per 2 gm. of liver. The reaction...
متن کاملThe mechanism of uncoupling of oxidative phosphorylation by 2,4-dinitrophenol.
2,4-Dinitrophenol fails to stimulate the breakdown of the soluble high energy intermediate of oxidative phosphorylation isolated from Alcaligenes faecalis extracts. Once the intermediate is broken down, by other reactions, the coupling enzyme is prevented from reassociation with the electron transport particles by 2,4-dinitrophenol. Phosphorylating particles washed with 2,4-dinitrophenol lose c...
متن کاملRespiration, oxidative phosphorylation, and uncoupling protein in Candida albicans.
The respiration, membrane potential (Deltapsi), and oxidative phosphorylation of mitochondria in situ were determined in spheroplasts obtained from Candida albicans control strain ATCC 90028 by lyticase treatment. Mitochondria in situ were able to phosphorylate externally added ADP (200 microM) in the presence of 0.05% BSA. Mitochondria in situ generated and sustained stable mitochondrial Delta...
متن کاملProtective effect of metronidazole on uncoupling mitochondrial oxidative phosphorylation induced by NSAID: a new mechanism.
BACKGROUND The pathogenesis of non-steroidal anti-inflammatory drug (NSAID) enteropathy is complex. It involves uncoupling of mitochondrial oxidative phosphorylation which alters the intercellular junction and increases intestinal permeability with consequent intestinal damage. Metronidazole diminishes the inflammation induced by indomethacin but the mechanisms remain speculative. A direct effe...
متن کاملProtonic conductance across phospholipid bilayer membranes induced by uncoupling agents for oxidative phosphorylation.
The chemiosmotic coupling hypothesis for oxidative phosphorylation proposed by Mitchell1 postulates that electron transport along the respiratory chain in the mitochondrial membrane generates a transmembrane pH gradient, which becomes the immediate driving force for the enzymatic synthesis of adenosine 5'-triphosphate (ATP) from adenosine 5'-diphosphate (ADP) and phosphate through the reverse a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1956
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65124-5